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目的探讨术前高敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)水平与冠脉药物支架(DES)植入术后再狭窄(ISR)的关系。方法检索维普中文期刊全文数据库、中国生物医学文献数据库、中国知网、PubMed数据库,收集相关原始研究;采用文献质量评价结合Meta分析的方法分析。结果 ISR组患者术前hs-CRP水平显著高于非ISR组的hs-CRP水平,中国人群和随访时间为6个月的亚组分析表明,ISR组患者术前hs-CRP水平显著高于非ISR组的hs-CRP水平。异质性分析显示纳入文献存在显著异质性。偏倚分析表明发表的文章不存在偏倚。结论术前hs-CRP水平与DES植入术后ISR的发生存在显著相关性。
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CRP水平与冠脉药物支架植入术后再狭窄关系的Meta分析
Association of C-reactive protein level with restenosis after coronary drug elute stenting: a meta-analysis
微创医学 201201期 页码：6-9
作者机构： 广西壮族自治区医学科学情报研究所
基金信息： 收稿日期: 2011-10-12
基金项目: 广西科技基础条件平台建设项目( 任务号: 10-108-18)
- 中文简介
- 英文简介
- 参考文献
Objective To explore the association of baseline high-sensitivity C-reactive protein ( hs-CRP) with in stent restenosis ( ISR) after coronary drug elute stenting ( DES) ． Methods PubMed，Vip Chinese Journal Full-text Databank，Chinese Biomedical Database ( CBM) ，Chinese National Knowledge Infrastructure ( CNKI ) and PubMed were retrieved for related primary studies． Literature qualification estimation combined Meta analysis were adopted to analysis． Results The baseline level of hs-CRP was significantly higher in ISR group than in no-ISR group． Subgroup analysis for Chinese population and the patients with 6 month follow-up was in agree with the mainly results． Heterogeneity analysis revealed a significantly heterogeneity across the studies． Funnel plots suggested little publication bias． Conclusions The baseline level of hs-CRP is significantly associated with the ISR after DES implantation．
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