Objective To evaluate the clinical effect and value of CT-guided percutaneous microwave ablation therapy for lung cancer． Methods Seventeen patients with peripheral lung cancer，totally 21 lesions， were treated with CT-guided percutaneous microwave ablation therapy under local anesthesia． The microwave energy was set at 2 450 MHz and 50 － 70 Watt． The treatment was conducted by using single or two points ablation emission according to the size and shape of the tumor． Ｒesults The operation time was 5 to 12 min ( mean，8 min) ． Operation was completed in all 17 patients，with a completion rate of 100%． Ｒight after microwave ablation，lower density or low CT value in the ablated area was observed in all patients． One month later，enhanced CT scanning revealed no enhancement in 18 nodules，partial enhancement in 3 patients，and a complete tumor necrosis in ablation zone． Three months later，enhanced CT scanning showed complete remission in 2 patients，partial remission in 10 cases，stable in 4 cases，and progress in 1 case，with an effective rate of 70． 59% ( 12 /17 ) ． Ｒelated complications，including pneumothorax in 3 cases，pleural effusion in 2 cases，and fever in 13 cases were observed． No needle track implantation was found，and no patient died within 30 postoperative days． During the follow-up of 3 to 30 months，13 patients were alive，with a median time of progress free survival ( PFS) of 14． 6 months． The 1 or 2-year survival rate was 94． 12% ( 16 /17) and 82． 35%( 14 /17) ， respectively． Conclusion Percutaneous microwave ablation therapy is minimally invasive， safe，and effective for lung cancer． It can improve the quality of life，delay the survival time，and improve the survival rate of lung cancer patients．

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