ObjectiveTo investigate the clinical effect of enhanced recovery after surgery (ERAS) combined with single-incision plus one-port laparoscopic surgery（SILS+1）radical resection of colorectal cancer in the treatment of colorectal cancer. MethodsA total of 100 patients with colorectal cancer were selected as the research objects and were divided into a control group and an observation group according to the random number table method, with 50 cases in each group. The control group received traditional laparoscopic radical resection of colorectal cancer (five-port method), and the observation group received SILS+1 (two-port method) radical resection of colorectal cancer. Patients in both groups received ERAS management during the perioperative period. The surgical conditions, postoperative recovery, and postoperative complications of the two groups were recorded and compared. Blood routine examination and visual analogue scale (VAS) were used to evaluate the postoperative inflammation and pain degree of the two groups. ResultsThe operation time and total incision length of the observation group were shorter than those of the control group, with statistically significant differences (all P＜0.05), but there was no statistically significant difference in intraoperative blood loss between the two groups (P＞0.05). One day after operation, the white blood cell count and the proportion of neutrophils in the two groups increased, but those in the observation group were lower than those in the control group, with statistically significant differences (all P＜0.05). One day after operation, the VAS score of the observation group was significantly lower than that of the control group, and the difference was statistically significant (P＜0.05). The first time of getting out of bed after operation and postoperative hospital stay in the observation group were shorter than those in the control group, and the differences were statistically significant (all P＜0.05). There was no statistically significant difference in the first anal exhaust time between the two groups after operation (P＞0.05). The incidence of postoperative complications was 4.0% (2/50) in the observation group and 10.0% (5/50) in the control group, and there was no statistically significant difference between the two groups (P＞0.05). ConclusionSILS+1 radical resection of colorectal cancer has a significant effect on colorectal cancer. Combined with ERAS management, it can significantly improve the operation efficiency, reduce the trauma and pain of patients, and is conducive to postoperative recovery.

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