ObjectiveTo investigate the related risk factors and recurrence of cervical intraepithelial neoplasia (CIN) with positive margin after conization. MethodsThe clinical data of 89 CIN patients treated with conization were retrospectively analyzed, and they were divided into positive margin (14 cases) and negative margin (75 cases) groups by the margin status to study the related risk factors and recurrence of positive margins after CIN conization and its recurrence. ResultsThe result of univariate analysis showed that the rates of patients aging ≥ 60 years old, with persistent human papilloma virus (HPV) infection, moderate to severe cervical erosion, cervical epithelial gland involvement, performed loop electrosurgical excisional procedure (LEEP) and with CIN grade Ⅲ in the positive margin group were higher than those in the negative margin group (all P＜0.05). There were no statistically significant differences between the two groups in maximum diameter of iodine non-stained area, gravidity, parity, body mass index (BMI), smoking history, drinking history, family history of cervical cancer, operation time and contact bleeding (all P＞0.05). Multivariate Logistic regression analysis showed that age ≥60 years old, persistent HPV infection, moderate to severe cervical erosion, cervical epithelial gland involvement, treated with LEEP, and CIN grade Ⅲ were independent risk factors for positive margin after CIN conization (all P＜0.05). After 6 months of follow-up, the recurrence rate of positive margin group was 21.43%, which was higher than that of negative margin group (1.33%) (P＜0.05). ConclusionThe positive margin of CIN after conization is closely related to a variety of factors, and the positive margin will increase the postoperative recurrence rate. Therefore, prevention and treatment should be strengthened according to each risk factor to improve the prognosis of patients.

无