ObjectiveTo investigate the efficacy and safety of transvaginal ultrasound positioning-guided laparoscopic myomectomy in the treatment of multiple uterine myoma. MethodsA total of 100 patients with multiple uterine myoma were selected as research objects, and they were divided into conventional group (n=43) and research group (n=57) according to the random number table method. Patients in the conventional group were treated with laparoscopic myomectomy, while patients in the research group were treated with transvaginal ultrasound positioning-guided laparoscopic myomectomy. The perioperative-related indexes (operation time, intraoperative blood loss, postoperative exhaust time, hospital stay), sex hormones levels before and 1 month after operation ［luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol (E2)］, the incidence of postoperative complications (congestion, incision infection, frequent urination) within 1 week after operation, the residual rate of uterine myoma 1 month after operation, and the relapse rate of uterine myoma 6 months after operation were compared between the two groups. ResultsThe operation time of the resreach group was longer than that of the conventional group (P＜0.05), and there was no significant difference in the intraoperative blood loss, postoperative exhaust time or hospital stay (all P＞0.05). Before and 1 month after operation, there was no statistically significant difference in LH, FSH, and E2 levels between the two groups (all P＞0.05). At 1 month after operation, the levels of LH and FSH in the two groups were higher than those before operation, whereas the levels of E2 were lower than those before operation (all P＜0.05). Within one week after operation, there was no significant difference in the incidence of congestion, incision infection or frequent urination between the two groups (all P＞0.05). One month after operation, the residual rate of uterine myoma in the research group was lower than that in the conventional group (P＜0.05). Within 6 months after operation, the relapse rate of uterine myoma in the research group was lower than that in the conventional group (P＜0.05). ConclusionIn the treatment of multiple uterine myoma, the transvaginal ultrasound positioning-guided laparoscopic myomectomy requires a longer operation time, but it yields lower postoperative residual rate and relapse rate of uterine myoma. Without increasing the intraoperative blood loss, postoperative exhaust time, hospital stay, and incidence of complications, it has a similar effect to conventional laparoscopic myomectomy, with good efficacy and high safety, and it is worthy of clinical promotion and application.

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