ObjectiveTo compare and analyze the effects of thoracoscopic pulmonary lobectomy and traditional open pulmonary lobectomy on the inflammatory factors levels, immune function, and cardiopulmonary function in early-stage lung cancer patients. MethodsA total of 114 early-stage lung cancer patients were selected as research subjects, and they were divided into study group (n=57) and control group(n=57) according to the treatment plan. The study group was treated with thoracoscopic pulmonary lobectomy, while the control group was treated with traditional open pulmonary lobectomy. The following indices were compared between the two groups of patients, including operation-related indices (incision length, number of dissected lymph nodes, operation time, intraoperative blood loss, and postoperative drainage), postoperative VAS scores, and the preoperative and postoperative immune function, inflammatory factors levels, and cardiopulmonary function. ResultsCompared with the control group, patients in the study group had shorter incision length and operation time, more dissected lymph nodes, and less intraoperative blood loss and postoperative drainage (all P＜0.05). The VAS scores of the study group 1 day, 3 days, and 7 days after the operation were lower than those of the control group (all P＜0.05). After the operation, the CD4+ T lymphocytes levels, CD8+ T lymphocytes levels, and the ratio of CD4+/CD8+ T lymphocyte levels in the two groups of patients were lower than those before the operation, and the levels of the above indices of the study group were higher than those of the control group (all P＜0.05). The levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), and C-reactive protein (CRP) of the two groups of patients after the operation were higher than those before the operation, and the levels of the above indices in the study group were lower than those in the control group (all P＜0.05). After the operation, the left ventricular ejection fraction (LVEF) of the two groups of patients was higher, the left ventricular end-systolic volume index (LVESVI), left ventricular end-diastolic dimension (LVEDD), left ventricular end-diastolic volume index (LVEDVI), and the ratio of early-diastolic mitral maximal blood flow velocity to the early-systolic mitral maximal blood flow velocity (E/A) were lower than those before the operation. Compared with the control group, the study group had higher LVEF and lower LVESVI, LVEDD, LVEDVI, and E/A after the operation ( all P＜0.05). The forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and FEV1/FVC in the two groups after the operation were lower than those before the operation, and the above indices in the study group were higher than those in the control group (all P＜0.05). ConclusionCompared with traditional open pulmonary lobectomy, thoracoscopic pulmonary lobectomy has a significant effect in the treatment of early-stage lung cancer and in lymph node dissection. The operation can shorten the operation time, reduce the intraoperative blood loss and postoperative drainage, and reduce the body′s inflammatory response, with little impact on the immune function and cardiopulmonary function, and causing mild postoperative pain in the patients, which is worthy of clinical application and promotion.

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