ObjectiveTo analyze the influencing factors for delayed cerebral ischemia (DCI) after minimally invasive clipping in patients with aneurysmal subarachnoid hemorrhage (aSAH). MethodsThe clinical data of 42 aSAH patients developed DCI a week after minimally invasive clipping were retrospectively analyzed, and the patients were enrolled to the development group. Another clinical data of 42 aSAH patients simultaneously receiving minimally invasive clipping but without developing DCI during postoperative follow-up were collected, and they were enrolled to the non-development group. Baseline information was compared between both groups, and logistic regression model was employed to analyze the influencing factors for DCI development after minimally invasive clipping in aSAH patients. ResultsThe development group expressed higher portions of patients complicated with hypertension or coronary heart disease, and higher level of serum miR-210 as compared with the non-development group (all P＜0.05). Logistic regression analysis interpreted that complicated with hypertension (OR=10.333, 95% CI: 3.771-28.319), or coronary heart disease (OR=13.600, 95% CI: 4.771-38.769), and elevated expression of serum miR-210 (OR=11.934, 95% CI: 4.248-33.529) were the risk factors for DCI development after minimally invasive clipping in aSAH patients (all P＜0.05). ConclusionaSAH patients complicated with hypertension or coronary heart disease, and with elevated expression of serum miR-210 etc., are associated with DCI development after minimally invasive clipping. Clinics may put forward targeted intervention regimen concerning the aforesaid factors, and it has positive significance for decreasing the incidence of DCI.

无