目的分析对剖宫产瘢痕妊娠患者行经阴道超声诊断的准确性及其影响因素。方法纳入200例疑似剖宫产瘢痕妊娠的患者进行分析,所有患者均接受经阴道超声检查和宫腔镜手术,并将最终的手术病理结果作为金标准,判断经阴道超声诊断的灵敏度、特异度及准确率。并对诊断结果采用Kappa检验,根据Kappa值进行一致性判断。根据手术病理结果将患者分为超声诊断无误组和超声诊断有误组,采用单因素和多因素Logistic回归模型分析经阴道超声诊断剖宫产瘢痕妊娠准确性的影响因素。结果(1)200例疑似剖宫产瘢痕妊娠患者中,169例患者的超声图像中可见宫腔内无妊娠囊,而子宫切口瘢痕处可见妊娠囊或杂乱回声结构,其中有78例子宫切口瘢痕处存在妊娠囊,56例子宫切口瘢痕处存在杂乱回声区,其余35例妊娠囊周围有高回声绒毛附着于子宫切口瘢痕处。(2)经阴道超声诊断灵敏度为91.21%、特异度为83.33%、准确率为90.50%,经阴道超声检查与宫腔镜检查的一致性为中等(Kappa=0.562)。(3)单因素分析显示:超声诊断无误组与超声诊断有误组患者在盆腔积液、混合性包块、孕囊距子宫切口瘢痕的距离方面差异有统计学意义(均P<0.05),而两组患者年龄、剖宫产次数、子宫肌瘤病史比较差异均无统计学意义(均P>0.05)。多因素Logistic回归分析显示,盆腔积液、混合性包块、孕囊距子宫切口瘢痕距离是影响经阴道超声诊断准确性的独立危险因素。结论经阴道超声检查可以对剖宫产瘢痕妊娠患者进行良好的检查以及判断,其具有较高的诊断准确率。但也存在多种因素对其诊断准确性造成影响,医生需适当对盆腔积液、混合性包块、孕囊距子宫切口瘢痕的距离等因素进行干预或处理。
ObjectiveTo analyze the diagnostic accuracy on patients with Cesarean scar pregnancy underwent transvaginal ultrasound and its influencing factors. MethodsA total of 200 patients suspected Cesarean scar pregnancy were enrolled and analyzed. All patients underwent transvaginal ultrasound and hysteroscopic operation, and the final operative and pathological findings were taken as the gold standard, to estimate the sensitivity, specificity and accuracy of diagnosis via transvaginal ultrasound. Kappa test was conducted on the results of diagnosis, to evaluate the consistency according to the value of Kappa. Patients were assigned to ultrasonic diagnosis without error group and ultrasonic diagnosis with error group according to the operative and pathological findings, and the univariate and multivariate logistic regression model were employed to analyze the influencing factors for the diagnostic accuracy on Cesarean scar pregnancy via transvaginal ultrasound. Results(1) A hundred and sixty nine of 200 patients suspected Cesarean scar pregnancy had ultrasonic image without gestation sac in uterine cavity, whereas with gestation sac or chaotic echo structure in uterine incision scar, among which 78 cases had gestation sac in uterine incision scar, 56 cases revealed chaotic echo area in uterine incision scar, and the remaining 35 cases had hyperechoic villi around gestation sac attached to uterine incision scar. (2) The diagnostic sensitivity, specificity and accuracy via transvaginal ultrasound were 91.21%, 83.33%, and 90.50%, and the consistency between examinations of transvaginal ultrasound and hysteroscopy was intermediate (Kappa=0.562). (3) Univariate analysis revealed that there were statistically significant differences in pelvic effusion, mixed mass, distance between gestation sac and uterine incision scar between the ultrasonic diagnosis without error group and the ultrasonic diagnosis with error group (all P<0.05), whereas with no statistically significant differences in age, times of Cesarean section, history of uterine fibroids between the two groups (all P>0.05). Multivariate logistic regression analysis interpreted that pelvic effusion, mixed mass, distance between gestation sac and uterine incision scar were the independent risk factors influencing the diagnostic accuracy via transvaginal ultrasound. ConclusionA favorable examination and estimation to patients with Cesarean scar pregnancy can be revealed via transvaginal ultrasound, which has high diagnostic accuracy; however, there are various factors influencing the diagnostic accuracy. Doctors should properly intervene or dispose those factors, including pelvic effusion, mixed mass, distance between gestation sac and uterine incision scar.