ObjectiveTo observe the effect of modified Xiaoliu decoction intervention on vascular endothelial growth factor (VEGF) and traditional Chinese medicine syndrome after colorectal cancer operation. MethodsA total of 200 patients after colorectal cancer operation were randomly divided into treatment group and control group, with 100 cases in each group. Both groups were given intraperitoneal chemohyperthermia. Combining with the method of traditional Chinese medicine syndrome differentiation, the treatment group was treated with modified Xiaoliu decoction according to the corresponding syndrome types. The levels of VEGF before and after treatment, and the improvement of life quality after treatment were compared between the two groups, as well as the therapeutic effect was evaluated based on the changes of clinical main symptoms of traditional Chinese medicine before and after treatment. ResultsAfter treatment, the levels of VEGF in the two groups decreased as compared with those before treatment, and the treatment group yielded a lower level compared to the control group (all P＜0.05). A significantly superior improvement of life quality revealed in the treatment group than in the control group (P＜0.05). The total effective rate of traditional Chinese medicine syndrome in the treatment group was 64.0% (64/100), with 29.0% (29/100) in the control group, and there was a statistically significant difference in the total effective rate between the two groups (P＜0.05). ConclusionXiaoliu decoction can inhibit the expression of VEGF in patients with colorectal cancer, which may have prevention on postoperative metastasis and recurrence in patients after colorectal cancer operation to a certain extent; meanwhile, it can effectively improve the traditional Chinese medicine syndrome and the life quality of patients.

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