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直肠癌并巨块型肝转移瘤同期行腹腔镜右半肝切除的治疗策略▲
Therapeutic strategy of simultaneously undergoing laparoscopic right hemihepatectomy for colorectal cancer with massive hepatic metastases

微创医学 20211604期 页码:457-460

作者机构:广西医科大学第二附属医院微创外科中心,广西南宁市530000

基金信息:▲基金项目:广西区卫健委自筹经费科研课题(编号:Z20190422) *通信作者

DOI:DOI:10.11864/j.issn.1673.2021.04.04

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目的探讨直肠癌并巨块型肝转移瘤同期行腹腔镜右半肝切除的治疗策略。方法对1例临床诊断为直肠癌并巨块型肝转移瘤的患者进行多学科联合诊治,包括进行严格的术前评估(残余肝体积测算),实施腹腔镜下直肠癌切除同期行解剖性右半肝切除、降结肠单腔造口术,术中予精准右半肝阻断、下腔静脉预阻断等措施防止术中出血。结果患者手术治疗过程顺利,术后病理为直肠中分化腺癌,累及肠壁全层并见肠周癌结节形成,13枚淋巴结中仅3枚出现转移,肝脏肿瘤符合肠癌肝转移。术后继续予规范化疗,术后6个月CT复查肝肺未见明显复发转移病灶。结论对于可根治切除的直肠癌并巨块型肝转移瘤患者应进行充分的术前评估,腹腔镜直肠癌切除同期行半肝切除安全有效。对首发症状为上腹胀痛不适,肿瘤标记物CEA、CA199升高并肝脏占位性病变患者,建议完善电子肠镜排查结直肠肿瘤肝转移,避免漏诊。
ObjectiveTo investigate the therapeutic strategy of simultaneously undergoing laparoscopic right hemihepatectomy for colorectal cancer with massive hepatic metastases. MethodsA patient diagnosed as colorectal cancer with massive hepatic metastases was conducted with clinic multidisciplinary diagnosis and treatment, including rigorous preoperative evaluation (residual liver volume measurement), and then laparoscopic resection of colorectal cancer was performed simultaneously with anatomic right hemihepatectomy and descending colon single cavity stoma, as well as right hemihepatic occlusion and preocclusion of inferior vena cava etc. were conducted during the operation to prevent intraoperative bleeding. ResultsThe surgery procedure of the patient was successful, and post-surgery pathology was moderately differentiated adenocarcinoma of the rectum, which the entire wall of the intestine was involved and the formation of periintestinal cancer nodules was seen. Only 3 of 13 lymph nodes had metastasis, and hepatic tumor was consistent with hepatic metastasis from colorectal cancer. Standard chemotherapy was continuously employed after surgery, CT reexamination of liver and lung 6 months after surgery presented no obvious recurrence of metastatic lesions. ConclusionFor patients with possible-radical-resection colorectal cancer with massive hepatic metastases, adequate preoperative evaluation should be conducted, and laparoscopic resection of colorectal cancer performed simultaneously with hemihepatectomy is safe and effective. For patients with initial symptoms as epigastric pain, elevation of tumor markers CEA and CA199, and hepatic space-occupying lesion, electronic colonoscopy to investigate colorectal carcinoma with hepatic metastasis is suggested improving, so as to avoid missed diagnosis.

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