ObjectiveTo investigate the expression and clinical significance of CLEC7A in intracranial aneurysms (IAA) tissues and serum. MethodsIAA gene dataset was searched in the GEO database to analyze the expression of CLEC7A in the IAA gene dataset and its relationship with age, gender of patients. A total of 60 serum specimens from IAA patients were collected, and other 20 serum specimens from healthy people were also collected as controls, the ELISA method was employed to detect serum CLEC7A expression, the relationship between CLEC7A expression in IAA serum and age, gender of patients was analyzed, and the value of serum CLEC7A level on diagnosing IAA was also analyzed. ResultsThe analysis results of two IAA gene dataset (GSE75436 and GSE54083) revealed that the expression of CLEC7A was significantly higher in IAA tissues than in normal arterial tissues (P＜0.05). The analysis result of GSE54083 dataset interpreted that there were no statistically significant differences in CLEC7A expressions in IAA tissues of different age groups and genders (all P＞0.05). The IAA patients obtained a significantly higher expression of serum CLEC7A as compared with the healthy people, and the people in high age (≥60 years of age) obtained a higher expression of serum CLEC7A in the comparison of the people in low age (＜60 years of age) (all P＜0.05). There was no statistically significant difference of serum CLEC7A expression between male and female patients (P＞0.05). Receiver operating characteristic (ROC) curve revealed that serum CLEC7A level had certain diagnostic value on IAA (with sensitivity in 0.618, and specificity in 0.700). ConclusionCompared to the indicators mentioned below in the healthy people, expressions of CLEC7A more significantly increased in IAA tissues and serum, which present that CLEC7A is closely correlated to the morbidity of IAA, and serum CLEC7A level can be used as one of the auxiliary diagnostic indicator of IAA.

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