ObjectiveTo investigate the effect of superior mesenteric artery interventional catheter thrombolysis on liver function and coagulation function in patients with cirrhosis complicated with portal vein thrombosis. MethodsA total of 60 patients with acute symptoms of cirrhosis complicated with portal vein thrombosis were randomly divided into control group and experimental group, with 30 cases in each group. The control group was treated with single anticoagulation (subcutaneous injection of low molecular weight heparin transited to oral administration of warfarin), while the experimental group was treated with superior mesenteric artery interventional catheter thrombolysis plus oral administration of warfarin. The changes of liver function, coagulation function, blood routine indexes before and after treatment, and post-treatment upper gastrointestinal bleeding were compared between the two groups. ResultsAfter 7 days of treatment, prothrombin time (PT) and international normalized ratio (INR) of the two groups were longer/higher than those before treatment, and PT of the experimental group was longer than that of the control group (all P＜0.05). After 6 months of treatment, the levels of white blood cells (WBC) count, hemoglobin (Hb), blood platelet (PLT) were higher than those before treatment, and the experimental group yielded a higher level of PLT as compared with the control group (all P＜0.05). After 6 months of treatment, the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) in the two groups were lower than those before treatment, whereas the level of albumin (ALB) was higher than that before treatment; moreover, the experimental group yielded lower levels of ALT, AST and ALP, while a higher level of ALB as compared with the control group (all P＜0.05). After 6 months of treatment, the levels of total bilirubin (TBIL) and direct bilirubin (DBIL) in the experimental group were significantly lower than those in the control group (all P＜0.05). There was no statistically significant difference in the upper gastrointestinal bleeding rate between the two groups after treatment (P＞0.05). ConclusionCompared with subcutaneous injection of low molecular weight heparin transited to oral administration of warfarin, superior mesenteric artery interventional catheter thrombolysis combined with oral administration of warfarin has superior effect on improving liver function of patients with cirrhosis complicated with portal vein thrombosis, and does not increase the influence on coagulation function and post-treatment upper gastrointestinal bleeding rate. It can be used as one of the schemes for the treatment of cirrhosis complicated with portal vein thrombosis.

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