ObjectiveTo analyze the clinical effect and safety of tissue adhesive combined with medication injection via endoscopy in the treatment of acute non-variceal upper gastrointestinal bleeding (ANVUGIB). MethodsA total of 82 patients with ANVUGIB were selected, and they were divided into study group and control group according to the treatment options, with 41 cases in each group. On the basis of routine treatment, the control group was given metal titanium clips or submucosal injection of 1 ∶10 000 adrenaline in bleeding lesions via endoscopy, while the study group received tissue adhesive combined with medication injection of exposed blood vessels via endoscopy. The surgical indicators (blood transfusion volume, hemostasis time, hospitalization time), clinical efficacy, success rate of hemostasis, rebleeding rate and complications were compared between the two groups. ResultsCompared with the control group, the study group yielded less volume of blood transfusion, shorter time of hemostasis and hospitalization, and higher total effective rate (97.56% vs. 78.05%, all P＜0.05). There were no statistically significant differences in hemostasis success rate and delayed rebleeding rate (all P＞0.05). The study group yielded lower rate of early postoperative rebleeding as compared with the control group (P＜0.05). After 1 to 2 months of treatment, no complications including gastrointestinal perforation and infection occurred in both groups, with a preferable effect of prognosis. ConclusionTissue adhesive combined with medication injection via endoscopy has a significant effect in the treatment of ANVUGIB, which can effectively reduce the volume of blood transfusion, shorten the time of hemostasis and hospitalization, decrease the incidence of rebleeding, with high safety, and thus it is worthy of clinical promotion and application.

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