目的比较不同剂量布托啡诺联合丙泊酚麻醉对宫腔镜检查患者镇痛效果及苏醒时间的影响。方法选择接受宫腔镜检查的患者150例,随机分为A组、B组、C组,每组50例。A、B、C组分别静脉注射布托啡诺10 μg/kg、15 μg/kg、20 μg/kg,三组均于3 min后静脉注射丙泊酚2.0 mg/kg,患者入睡后开始行宫腔镜检查操作,术中根据患者体动等情况追加丙泊酚。记录三组患者手术时间、丙泊酚用量、术中体动发生率、术后苏醒时间,采用数字评分法(NRS)评价患者苏醒后30 min宫缩痛程度。结果三组手术时间差异无统计学意义(P>0.05)。A组患者丙泊酚用量明显多于B组、C组,苏醒后30 min的宫缩痛NRS评分高于B组、C组(均P<0.05),而B组与C组上述指标比较,差异均无统计学意义(均P>0.05)。B组患者术后苏醒时间明显短于A组、C组,而A组术中体动发生率明显高于B组、C组(均P<0.05),B组和C组术中体动发生率差异无统计学意义(P>0.05)。结论在宫腔镜检查中采用15 μg/kg剂量的布托啡诺联合丙泊酚进行麻醉,麻醉效果确切,可明显缩短患者术后苏醒时间,减少丙泊酚用量和降低术后宫缩痛程度。
ObjectiveTo compare the effects of different doses of butorphanol combined with propofol anesthesia on the analgesic effect and recovery time in patients undergoing hysteroscopy. MethodsA total of 150 cases of patients received hysteroscopy were selected and randomly divided into group A, group B and group C, with 50 cases in each group. Group A, B, C were injected with butorphanol for 10 μg/kg, 15 μg/kg, 20 μg/kg, respectively. Three minutes later, all three groups received intravenous injection of propofol 2.0 mg/kg. Hysteroscopy was performed after patients falling asleep, and propofol was additionally administrated according to the body movement in patients during the operation. The operative time, propofol dosage, incidence of intraoperative body movement and postoperative recovery time were recorded in three groups. The numerical rating scale (NRS) was used to evaluate the degree of uterine contraction pain 30 minutes after recovery. ResultsThere was no statistically significant difference in operation time among the three groups (P>0.05). Compared with group B, C, group A yielded a significantly larger dosage of propofol, and a higher NRS score of uterine contraction pain 30 minnutes after recovery (all P<0.05), but there were no statistically significant differences in the above indexes between group B and group C (all P>0.05). Group B yielded shorter postoperative recovery time as compared with group A and group C, while group A yielded higher incidence of intraoperative body movement compared to group B and group C (all P<0.05). There was no statistically significant difference in the incidence of intraoperative body movement between group B and group C (P>0.05). ConclusionDuring hysteroscopy, using butorphanol at a dosage of 15 μg/kg combined with propofol for anesthesia has a definite anesthetic effect, which can significantly shorten the postoperative recovery time, reduce the dosage of propofol and the degree of postoperative uterine contraction pain.