ObjectiveTo investigate the efficacy of intravitreal ranibizumab injection combined with 25G vitrectomy in the treatment of diabetic retinopathy (DR). MethodsEighteen patients (27 eyes in total) with DR were selected; of them, 9 cases (15 eyes) treated with intravitreal injection of ranibizumab combined with 25G vitrectomy were enrolled in observation group, and 9 cases (12 eyes) treated with simple 25G vitrectomy during the same period, whose general data were comparable with the observation group, were enrolled in control group. The clinical efficacy, operation time, visual acuity, macular retinal thickness and complications were compared between the two groups. ResultsThe observation group yielded a higher total effective rate ［93.33% (14/15) vs. 50.00% (6/12)］，shorter operation duration, and a lower incidence of complications ［6.67% (1/15) vs. 41.67% (5/12)］ as compared to the control group. After treatment, the visual acuities in both groups were higher than those before treatment, and visual acuity in the observation group was higher than that in the control group. The macular retinal thicknesses of the two groups were smaller than those before treatment, and the thickness of the observation group was smaller than that of the control group. The above differences were statistically significant (all P＜0.05). ConclusionIntravitreal injection of ranibizumab combined with 25G vitrectomy has a significant effect on DR, which can shorten the operation duration and reduce the risk of complications. It is worth promoting and applying.

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