ObjectiveTo investigate the clinical effect of modified Miccoli operation endoscopic thyroidectomy in the treatment of early differentiated thyroid cancer. MethodsA total of 82 patients with early differentiated thyroid cancer were selected and were divided into control group and observation group by the random number table method, with 41 cases in each group. The control group was treated with traditional thyroid surgery, and the observation group was treated with modified Miccoli operation endoscopic thyroid surgery. The operation related indexes, incidence of postoperative complications and quality of life (QOL) scores before and after operation were observed and compared between the two groups. ResultsThere was no statistically significant difference in the number of lymph node dissection between the two groups (P＞0.05). The operation time, intraoperative blood loss, postoperative drainage, incision length and hospital stays of the observation group were significantly shorter/less than those of the control group，and the total incidence of complications of the observation group was significantly lower than that of the control group (all P＜0.05). The QOL scores increased in both groups after operation, and the scores were significantly higher in the observation group than in the control group (all P＜0.05). ConclusionModified Miccoli operation endoscopic thyroidectomy for early differentiated thyroid cancer has a significant clinical effect and a high safety, which can improve the quality of life in patients.

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