ObjectiveTo investigate the effect of suberect spatholobus stem on hypoxia tolerance in mice. MethodsSixty mice were randomly divided into suberect spatholobus stem group, rose-boot group and normal saline group, with 20 mice in each group. Mice in the suberect spatholobus stem group intragastrically administered prepared suberect spatholobus stem decoction, with 0.5 mL per mouse; mice in the rose-boot group intragastrically administered prepared rose-boot decoction, with 0.5 mL per mouse, and the mice in the normal saline group intragastrically administered the same dose of normal saline. The mice received daily intragastric administration for 10 days. On the 11th day, the hypoxia tolerance of mice in each group was measured at room temperature 25 ℃ and the normal pressure. The red blood cell (RBC) count, hemoglobin (HGB) content and mean corpuscular hemoglobin (MCH) content were measured by additional blood drawing. ResultsThe oxygen consumption rate of mice in the suberect spatholobus stem group (0.037 4±0.007 0) was significantly lower than that in the normal saline group (0.052 8±0.010 3) (P＜0.05), but the difference of the rate was not statistically significant between the suberect spatholobus stem group and the rose-boot group (0.035 5±0.007 5) (P＞0.05). The levels of RBC, HGB and MCH in the suberect spatholobus stem group were higher than those in the normal saline group (all P＜0.05); there were no statistically significant differences in the levels of RBC, HGB and MCH between the suberect spatholobus stem group and the rose-boot group (all P＞0.05). ConclusionSuberect spatholobus stem decoction can improve the hypoxia tolerance of mice.

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