ObjectiveTo investigate the effect of laparoscopic-assisted D2 radical resection on the clinical efficacy and survival rate in patients with advanced gastric cancer. MethodsA total of 147 patients with advanced gastric cancer were selected, and they were divided into laparoscopy group（n=75) and laparotomy group (n=72) by the random number table method. The laparoscopy group was treated with laparoscopic-assisted D2 radical resection, whereas the laparotomy group was treated with conventional open D2 radical resection. The basic information of surgery (surgical incision length, operative time, intraoperative bleeding volume, postoperative first anal exhaust time), tumor radical indicators (total number of lymph nodes dissection, distance from distal and proximal resection end to the tumor), the incidence of complications, the survival rate and recurrence rate were compared between the two groups. ResultsThe laparoscopy group had longer operative time, a shorter length of the incision and postoperative first anal exhaust time, less intraoperative bleeding volume, as well as a lower complications rate as compared with the laparotomy group (all P＜0.05). There were no statistically significant differences in the total number of lymph nodes dissection, and the distance from the distal and proximal resection end to the tumor between the two groups (all P＞0.05). The one-, three- and five-year survival rates of patients in the laparoscopy group and the laparotomy group were 89.21%, 63.07%, 55.42%, and 89.78%, 61.47%, 57.83%, respectively, without statistically significant differences between the two groups (all P＞0.05). During follow-up, there was no statistically significant difference in the recurrence rate between the two groups (45.07% vs. 51.52%, P＞0.05). ConclusionLaparoscopic-assisted radical resection for advanced gastric cancer is a safe and feasible surgical treatment.

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