ObjectiveTo analyze the influencing factors for recurrent fractures after vertebroplasty for osteoporotic vertebral compression fracture (OVCF). MethodsThe clinical data of 168 patients with OVCF undergoing vertebroplasty from January 2017 to June 2019 were retrospectively analyzed. According to the regular return visits 1-3 months after operation, the patients with recurrent fractures were enrolled into recurrent fracture group, while those without recurrent fractures were enrolled into non-recurrent fracture group. The clinical data were analyzed by univariate analysis. By means of receiver operating characteristic (ROC) curve to analyze the cut-off values of influencing factors, multivariate logistic regression analysis was used to explore the influencing factors for recurrent fracture after vertebroplasty for osteoporotic vertebral compression fracture. ResultsAccording to the regular return visits 1-3 months after operation, 33.33% (56/168) recurrent fracture occurred, whereas patients without recurrent fracture accounted for 66.67% (112/168). There were statistically significant differences in age, diabetes mellitus, bone mineral density (BMD), procollagen type I N-terminal propeptide (P1NP), alkaline phosphatase (ALP) and bone Gla protein (BGP) between the recurrent fracture group and the non-recurrent fracture group (all P＜0.05). Logistic regression analysis interpreted that age ≥60 years old, combined with diabetes mellitus, BMD ≤ 0.45 g/m2, P1NP ≤ 35.75 ug/L, ALP ≤ 84.76 IU/L, and BGP ≤ 1.64 ug/L were the independent risk factors for recurrent fracture after vertebroplasty for OVCF (P＜0.05). ConclusionAdvanced age, combined with diabetes mellitus and decrease of BMD, ALP, P1NP and BGP have closely correlation with recurrent fracture after vertebroplasty for OVCF. Focusing on these risk factors in the diagnosis and treatment process has a certain guiding value in preventing recurrent fractures after vertebroplasty for OVCF.

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