ObjectiveTo investigate the effects of hysteroscopic surgery on interleukin-6 (IL-6) and soluble CD40 ligand (sCD40L) levels in patients with hysteromyoma. MethodsA total of 100 patients with hysteromyoma were divided into observation group and control group by the random number table method, with 50 cases in each group. The control group was treated with laparoscopic myomectomy, while the observation group was treated with hysteroscopic myomectomy. The operation time, intraoperative blood loss, postoperative anal exhaust time, hospital stays, number of myomectomies, serum IL-6, sCD40L levels before and after surgery, and complications were compared between the two groups. ResultsThe observation group yielded longer operation time, less intraoperative blood loss, hospital stays, number of myomectomies, earlier postoperative anal exhaust time, and lower incidence of postoperative complications as compared with the control group (all P＜0.05). After surgery, the levels of serum IL-6 in both groups significantly increased, and sCD40L level significantly decreased compared to those before surgery, following statistically significant differences between the observation group and the control group (all P＜0.05). ConclusionHysteroscopic myomectomy is safe and effective in the treatment of hysteromyoma, following the advantages of less intraoperative bleeding volume and postoperative complications, which is of preferable clinical promotion value as compared with laparoscopic surgery.

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