ObjectiveTo study the effect of endoscopic submucosal dissection (ESD) in the treatment of early esophageal cancer and its influence on serum tumor markers. MethodsA total of 74 patients with early esophageal cancer were selected and divided into control group and study group according to the randomized double-blind principle, with 37 cases in each group. The control group was given traditional open resection, and the study group was treated with ESD. Clinical indicators, pre- and postoperative serum tumor markers and quality of life scores, as well as the conditions of complications and prognosis were compared between the two groups. ResultsThe study group had shorter operation time, postoperative fasting time, postoperative bed rest time and hospital stays, and less intraoperative blood loss, as well as a lower total incidence of complications ( 8.11% vs. 27.03%) as compared with the control group (all P＜0.05). After treatment, the levels of serum tumor markers (CYFRA21-1, NSE, SSCA, and CEA) in the study group were significantly lower than those in the control group, and various factors scores of the health-promoting lifestyle profile-Ⅱ(HPLP-Ⅱ) scale were significantly higher than those in the control group (all P＜0.05). There were no statistically significant differences in the incidence of recurrence and metastasis between the two groups (all P＞0.05). ConclusionESD treatment can significantly improve the clinical indicators, reduce the levels of serum tumor markers, improve the quality of life, and improve the conditions of complications and prognosis for patients with early esophageal cancer.

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