ObjectiveTo explore the clinical effect and safety of drug-loaded microspheres transcatheter arterial chemoembolization (TACE) for treating liver cancer. MethodsA total of 126 patients with liver cancer undergoing TACE therapy were assigned to control and observation groups by the double chromosphere method, with 63 cases in each group. The control group was administered conventional TACE, whereas the observation group was administered drug-loaded microspheres for treatment. The therapeutic effect and liver function indexes levels before and after surgery were compared, and the adverse reactions, as well as the survival status, were analyzed in the two groups. ResultsThe therapeutic effect in the observation group was significantly superior to that in the control group (P＜0.05). One week after surgery, the levels of total bilirubin (TBIL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and prothrombin time (PT) of the two groups increased, and the observation group yielded lower levels of TBIL and ALT, but higher levels of AST and PT as compared with the control group (all P＜0.05). Three months after surgery, there was no statistically significant difference in the survival rate between the two groups (P＞0.05). Twelve months after surgery, the observation group yielded a higher survival rate, and a lower total incidence of adverse reactions as compared with the control group (4.76% vs. 15.87%, P＜0.05). ConclusionDrug-loaded microspheres TACE can prominently increase the short-term efficacy and long-term survival rate of patients, improve liver function, and increase the safety of the treatment.

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