ObjectiveTo explore the clinical efficacy of ozone combined with sodium hyaluronate for treating knee osteoarthritis. MethodsA total of 130 patients with knee osteoarthritis were divided into three groups in accordance with the random number table method, the sodium hyaluronate group (43 cases) received intra-articular injection of 25 mg sodium hyaluronate , the ozone group (44 cases) received intra-articular injection of 10 mL ozone (at a concentration of 20 μg/mL), and the mixed treatment group (43 cases) received intra-articular injection of 10 mL ozone in the first and third week followed by intra-articular injection of 25 mg sodium hyaluronate in the second and forth week, with four-time injection per month in total. After three-consecutive-month observation, knee joint pain, knee joint function, clinical efficacy, and adverse reactions were compared between the three groups. ResultsAfter treatment, the VAS scores decreased in the three groups compared with the scores before treatment, and the scores in the mixed treatment group were lower than those in the sodium hyaluronate and ozone groups (all P＜0.05), but there was no statistically significant difference between the sodium hyaluronate group and the ozone group (P＞0.05). The total effective rate of the mixed treatment group (97.67%) was higher than that of the sodium hyaluronate (79.07%) and the ozone groups (75.00%) (all P＜0.05). There was no statistically significant difference in the incidence of adverse reactions between the three groups. ConclusionOzone combined with sodium hyaluronate has a synergistic effect in the treatment of knee osteoarthritis, which can improve clinical efficacy.

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