ObjectiveTo investigate the risk factors for the progression of coronary artery lesions after percutaneous coronary intervention (PCI). MethodsA total of 421 patients who were diagnosed as coronary heart disease by coronary angiography (CAG) and underwent PCI were selected, then they were divided into progressive group (263 cases) and non-progressive group (158 cases) according to the results of postoperative coronary angiography review. Gender, age, smoking history, hypertension history, as well as the levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-H), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein of the two groups were analyzed and compared so as to screen out the risk factors for the progression of coronary artery lesions after PCI. ResultsThe progressive group yielded higher rates of abnormal baseline and review LDL-C, higher levels of TC and LDL-C, as well as a higher rate of abnormal review TC and a higher apolipoprotein B(ApoB) level compared to the non-progressive group (all P＜0.05). Multivariate logistic regression analysis showed that number of stents implanted, abnormal LDL-C at baseline and review, and high ApoB level at review were the independent risk factors for progression of coronary artery lesions after PCI（all P＜0.05). Patients with normal review LDL-C after PCI obtained lower rate and degree of coronary artery diseases progression; whereas among patients with normal baseline and review LDL-C, those with review LDL-C level lower than the baseline yielded lower lesion progression degree (all P＜0.05). ConclusionNumber of stents implanted, abnormal LDL-C, and high ApoB level are the independent risk factors for the progression of coronary heart lesions after PCI. Further decline in LDL-C level after normalization may retard the progression of coronary artery lesions. Patients should pay more attention to blood lipid regulation after PCI.

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