ObjectiveTo explore the efficacy of microscopic tumor resection for brain gliomas and to analyze the risk factors for brain gliomas recurrence. MethodsThe clinical data of 60 patients with brain gliomas underwent microscopic tumor resection were analyzed retrospectively. Efficacy and related risk factors for recurrence were summarized. ResultsAll of the 60 patients underwent microscopic tumor resection successfully without death. Fifty-five (91.67%) patients survived more than one year and 50 (83.33%) patients more than two years. Patients obtained significantly higher life quality scores 1 year after surgery compared to preoperation (all P＜0.05). For two-year follow-up, there were 15 recurrent cases (recurrence group) and 45 cases without recurrence (non-recurrence group) after surgery. The results of univariate analysis showed that there were no statistically significant differences in gender or tumor location between the two groups (all P＞0.05); there were statistically significant differences in age, tumor size, tumor morphology, pathological grade, surgical resection extension, expression of proliferating cell nuclear antigen (PCNA), matrix metalloproteinase 9 (MMP-9) and OY-TES-1 protein mRNA between the two groups (all P＜0.05). Multivariate analysis indicated that tumor diameter＞6 cm, high-grade brain glioma, subtotal resection and positive expression of OY-TES-1 mRNA were independent risk factors for recurrence (all P＜0.05). ConclusionAfter microscopic tumor resection, patients with brain glioma have a high survival rate, and their life quality is improved significantly, achieving high surgical safety. Tumor diameter, grade of brain gliomas, and operation approaches might affect the recurrence of brain gliomas.

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