ObjectiveTo investigate the clinical significance of narrow-band imaging magnifying endoscopy (NBI-ME) combined with endoscopic ultrasonography (EUS) in the diagnosis of early esophageal cancer (EEC) and the prediction of lesion invasion depth. MethodsThe clinical data of 44 patients with highly suspected EEC and undergoing NBI-ME and EUS examination were retrospectively analyzed. With pathological diagnosis as the gold standard, the diagnosis value of NBI-ME for esophageal lesions nature by intrapapillary capillary loop (IPCL) classification and the predictive effect of EUS on the depth of lesion invasion were analyzed. Results(1) The accuracy rate of NBI-ME in identifying EEC and precancerous lesions was 95.45% (42/44), with a satisfactory consistency with biopsy pathology (Kappa=0.810). (2) Thirty-nine of 44 enrolled patients underwent surgical resection in our hospital. With the postoperative pathological stage as the gold standard, the overall accuracy rate of EUS in the prediction of lesion invasion depth was 79.49% (31/39), with a favorable consistency with postoperative pathological stage (Kappa=0.626). (3) The overall accuracy rate of EUS combined with NBI-ME for EEC invasion depth increased to 94.87%(37/39), with a satisfactory consistency with postoperative lesion invasion depth (Kappa=0.904). (4) A statistically significant difference was observed in accuracy for identifying esophageal lesion depth between NBI-ME combined with EUS and simple EUS (P＜0.05). ConclusionObserving IPCL of esophageal lesions on NBI-ME and conducting AB classification are conducive to identifying esophageal lesions nature; and its combination of EUS examination can predict the depth of lesion invasion and evaluate lesions comprehensively, thus developing the optimum treatment plan for patients.

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