ObjectiveTo study the causality between risk factors for patients with atherosclerotic cerebral infarction (ACI) and mean platelet volume (MPV), and to determine whether MPV enlargement is an independent risk factor for ACI. MethodsA total of 300 patients diagnosed with ACI were selected as observation subjects, and their clinical information on MPV were recorded. Multivariate analysis and Granger causality analysis were conducted in groups by time, and MPV-related risk factors for ACI and their causality were determined. ResultsMultivariate analysis revealed that the factors significantly associated with MPV (P＜0.05) were as follows: platelet count (PC), Oxfordshire Community Stroke Project (OCSP) type 4 (lacunar infarction), leukoaraiosis and white blood cell (WBC) count. Granger causality analysis of quantitative indicators, including MPV, WBC count and PC, was performed, and PC was the Granger cause of MPV variance; WBC count had a relatively strong predictive effect on MPV variance, which might be the Granger cause. ConclusionMPV variance results from the combined action of multiple factors such as atherosclerotic thrombosis. There is still no sufficient evidence provided to prove that MPV variance in platelet activation is an independent risk factor for ACI.

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