ObjectiveTo investigate the expression of scar formation-related factors ［transforming growth factor β(TGF-β) subtype and α smooth muscle actin (α-SMA)］ after holmium laser-caused ureteral injury. MethodsQuantitative reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the expression levels of TGF-βsubtypes (TGF-β1, TGF-β2, TGF-β3) and α-SMA in normal rabbit ureter and injured rabbit ureter caused by holmium laser, and the data were statistically analyzed. ResultsCompared with normal rabbit ureter, injured rabbit ureter caused by holmium laser exhibited notably elevated expression of TGF-β1, TGF-β2 and α-SMA after 3 weeks of injury(P＜0.05), but no statistically significant difference was found in TGF-β3 expression between the two groups(P＞0.05). ConclusionHolmium laser-caused ureteral thermal injury results in changes in the expression of TGF-β subtype andα-SMA, which is closely related to the formation of ureter scar and the occurrence of ureter stricture.

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