ObjectiveTo investigate the changes of serum myocardial markers before and after interventional treatment of ventricular septal defect. MethodsSixty-nine children receiving interventional treatment of ventricular septal defect were enrolled as the subjects. Serum myocardial markers of the children before and after treatment were analyzed and compared, such as serum troponin I (cTnI), creatine kinase (CK), creatine kinase isoenzyme MB (CK-MB), lactate dehydrogenase (LDH), aspartate aminotransferase (AST) and high-sensitivity C-reactive protein (hs-CRP). ResultsOf the 69 children, 67 children achieved successful interventional treatment, with a success rate of 97.10% and an operation duration of 82.15±26.37 minutes. Occluder withdrawal was performed in one child because the occluder could not completely cover the defect, and another case gave up occluder use due to a third-degree atrioventricular block when the orbit was established. Compared with the preoperative level, cTnI level increased significantly at 6 hours after operation in children with ventricular septal defect and began to decrease at 12 hours after operation, presenting statistically significant differences (P＜0.05); there was no statistically significant difference between the cTnI level at 48 hours after operation and the preoperative level (P＞0.05). The postoperative 6-, 12-, 24- or 48-hour CK, CK-MB, LDH, or AST level did not statistically differ from the preoperative level (P＞0.05). The postoperative 6-, 12-, 24- and 48-hour hs-CRP levels were significantly higher than that before operation, presenting statistically significant difference (P＜0.05). ConclusionThe levels of cTnI and hs-CRP show a certain fluctuation in children after interventional treatment of ventricular septal defect, which may be related to the prognosis of interventional therapy. Further follow-up studies are needed for verification.

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