ObjectiveTo investigate the risk factors for in-stent restenosis (ISR) after cerebral artery stenting. MethodsThe clinical data of 103 patients with severe cerebral artery stenosis confirmed by digital subtraction angiography (DSA) and CT angiography (CTA) were retrospectively analyzed. The patients were reexamined by DSA and CTA within 60 months after discharge. ISR served as the end point. Thirty-four patients with postoperative restenosis were enrolled in the restenosis group, while 69 patients without restenosis were enrolled in the control group. Univariate and multivariate Cox survival analysis of causes of restenosis were performed. ResultsUnivariate analysis revealed that mean platelet volume (MPV), cigarette and drink abuse, and basilar artery probably correlated with restenosis in the two groups(P＜0.1). There were no statistically significant differences between the two groups in age, gender, complications, homocysteine(Hcy) level, or platelet(PLT) (P＞0.05). Multivariate Cox survival analysis revealed that basilar artery (P=0.043, HR=3.044) and MPV (P=0.045, HR=0.612) were significant correlative factors for forward Logistic regression method; basilar artery (P=0.015, HR=3.950), gender (P=0.071, HR=0.465), age (P=0.088, HR=1.033), and MPV (P=0.065, HR=0.624) were significant correlative factors for backward Logistic regression method. ConclusionFemale, advanced age, and basilar artery stenting are risk factors for ISR. Chronic platelet depletion reflected by long-term increase of MPV is a protective factor for ISR.

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