ObjectiveTo investigate the clinical effect of early minimally invasive percutaneous peritoneal drainage on severe acute pancreatitis (SAP). MethodsThe clinical data of 63 patients with SAP were analyzed retrospectively. According to the duration between admission and minimally invasive percutaneous peritoneal drainage, the patients were divided into observation group (33 cases; duration between admission and minimally invasive percutaneous peritoneal drainage ≤ 1 week) and control group (30 cases; duration between admission and minimally invasive percutaneous peritoneal drainage ＞1 week). Duration of abnormal symptoms and signs, duration of abnormal blood amylase, duration of abnormal serum endotoxin, extension of pancreatic necrosis during hospitalization, levels of inflammatory factors, and related conditions of ultrasound-guided percutaneous catheter drainage (PCD) after minimally invasive percutaneous peritoneal drainage were compared between the two groups. The conditions of organ failure and infection during treatment and hospitalization-related conditions were statistically analyzed. ResultsThe duration of abnormal symptoms and signs, durations of abnormal blood amylase and endotoxin in the observation group were shorter than those in the control group（P＜0.05）. There was no statistically significant difference between the two groups in extension of pancreatic necrosis during hospitalization（P＞0.05）. No statistically significant difference was observed between the two groups in levels of inflammatory factors at admission（P＞0.05）. Before PCD, the levels of tumor necrosis factor(TNF)-α, C-reactive protein(CRP), interleukin(IL)-6 and IL-10 were decreased in the two groups compared with the levels at admission（P＜0.05）, and the observation group had lower levels than the control group（P＜0.05）. The observation group exhibited longer duration between disease onset and initial PCD, less number of PCD tubes per capita, and shorter duration of PCD drainage than the control group（P＜0.05）. There were no statistically significant differences between the two groups in number of PCD operations per capita or incidence rate of PCD-related complications（P＞0.05）. In the observation group, the duration of organ failure and hospital stay were shorter, and the hospitalization expenses was less than those in the control group（P＜0.05）. No statistically significant differences were observed between the two groups in rate of multiple bacterial infection, rate of single bacterial infection, rate of organ failure, mortality, or ICU stay（P＞0.05）. ConclusionFor SAP patients, early minimally invasive percutaneous peritoneal drainage is of great significance in alleviating clinical symptoms and signs, preventing organ failure and improving inflammatory reaction.

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