ObjectiveTo evaluate the degree of body trauma caused by endoscopic thyroidectomy via areola approach. MethodsA total of 60 patients with benign thyroid tumors were enrolled as subjects, among which, 30 cases receiving endoscopic thyroidectomy via areola approach were enrolled as observation group and 30 cases receiving conventional open surgery as control group. At 1 day before surgery, and at 24 h, 48 h and 72 h after operation, the variations of serum cortisol (CORT) , tumor necrosis factor alpha(TNF-α), interleukin 6(IL-6), C reactive protein(CRP), white blood cell(WBC), blood glucose(BG) and body temperature(BT) were statistical analyzed in both groups. ResultsThere was no significant difference in the serum CORT level at 1 day before surgery between the two groups（P＞0.05）; At 24 h, 48 h and 72 h after operation, the serum CORT levels of the control group were higher than those of the observation group（P＜0.05）. In both groups, the TNF-α,IL-6,CRP and WBC at 24 h, 48 h and 72 h after operation were significantly higher than those at 1 d before surgery（P＜0.05）; At the same time point, there were no significant differences in the TNF-α,IL-6,CRP,WBC,BG and BT between the two groups (P＞0.05). In the observation group, no significant changes were found in the postoperative BG and BT levels compared to the preoperative levels（P＞0.05）. In the control group, the BG at 24 h after operation ,and BT at 24 h and 48 h after operation were significantly higher than those at 1 d before operation（P＜0.05）, but no statistical differences in the BG and BT were found among the rest time points (P＞0.05). ConclusionCompared to conventional open thyroidectomy, endoscopic thyroidectomy via areola approach does not increase trauma to the body.

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