ObjectiveTo analyze the clinical efficacy of minimally invasive sequential therapy for hemifacial atrophy below the severe level. MethodsNine patients with hemifacial atrophy below the severe level received minimally invasive sequential therapy consisting of 3D-printed titanium mesh implantation, autologous cartilage transplantation and transplantation by autologous fat particles injection. ResultsTreatment was completed successfully in all the 9 patients. After operation, natural fullness and smooth facial lines were observed in the previous sunken parts of the patients′ faces, and no complications such as subcutaneous mass, infection, and rejection, displacement and deformation of implant were found during follow-up. Satisfactory degree was relatively high and self-confidence was greatly improved in the patients. ConclusionFor hemifacial atrophy below the severe level, minimally invasive sequential therapy can achieve a therapeutic effect without facial incision and a natural postoperative cosmetic effect with simple manipulation and mild trauma, and is safe and reliable.

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