ObjectiveTo explore the efficacy of laparoscopic repair of gastroduodenal perforation for treating gastric perforation. MethodsEighty-four patients with gastric perforation were randomly divided into study group and control group, with 42 cases in each group. The study group and control group were treated with laparoscopic repair of gastroduodenal perforation and open repair of gastric perforation respectively. The relevant operative indices, preoperative and postoperative gastrointestinal syndrome scores, preoperative and postoperative pepsase（PGⅠand PGⅡ）levels and gastrointestinal hormones (GAS and VIP) levels, and the incidence of postoperative complications were compared between the patients of the two groups. ResultsCompared to the control group, the intraoperative blood loss, duration for anal exhaust, postoperative hospital stay and incident rate of postoperative complications were lower or shorter in the study group（all P＜0.05）. The postoperative scores of bowel sound, abdominal distention and pain, and gastrointestinal reaction were lower in both groups than the preoperative scores, and the postoperative score of each item in the study group was lower than that in the control group (all P＜0.05). The postoperative levels of PGⅠ, PGⅡ, GAS and VIP were higher in both groups than the preoperative levels, and the postoperative levels of PGⅠ, PGⅡ, GAS and VIP in the study group were higher than those in the control group (all P＜0.05). ConclusionFor treating gastric perforation, laparoscopic repair of gastroduodenal perforation can reduce the surgical trauma, is beneficial to the postoperative recovery, improves the syndromes and gastrointestinal hormones of patients, and reduces the postoperative complications.

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