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腹腔镜手术对胃间质瘤患者生活质量及机体免疫功能的影响
Effect of laparoscopic surgery on quality of life and body′s immune function in patients with gastric stromal tumor

微创医学 201813卷06期 页码:732-734

作者机构:东南大学医学院附属盐城医院普外科,江苏省盐城市224000

基金信息:*通信作者

DOI:10.11864/j.issn.1673.2018.06.08

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  • 英文简介
  • 参考文献
目的探讨腹腔镜手术对胃间质瘤患者生活质量及机体免疫功能的影响。方法选择30例胃间质瘤患者为观察对象,按随机数字表法分为观察组和对照组,每组15例。对照组采用传统开放手术治疗,观察组采用腹腔镜肿瘤切除术治疗。比较两组患者手术情况、术后并发症发生率、生活质量及机体免疫功能指标。结果观察组手术时间、住院时间、术中出血量、并发症发生率均低于对照组(均P<0.05)。观察组术后CD3+、CD4+细胞阳性率、CD4+/CD8+比值均高于对照组,而CD8+细胞阳性率低于对照组(均P<0.05)。术后两组卡氏评分量表(KPS)评分均显著升高,且观察组KPS评分高于对照组(均P<0.05)。结论腹腔镜手术治疗胃间质瘤,具有创伤小、术后恢复快、安全性高等优势,且对机体免疫功能影响小,可提高患者术后生活质量。
ObjectiveTo explore the effect of laparoscopic surgery on the quality of life and body′s immune function in the patients with gastric stromal tumor. MethodsThirty patients with gastric stromal tumor were enrolled as objects, and were divided into observation group and control group using random number table, with 15 cases in each group. The control group was treated with conventional open surgery, and the observation group was treated with laparoscopic tumorectomy. The operative condition, incident rate of postoperative complications, quality of life and body′s immune function were compared between the patients in the two groups. ResultsThe duration of operation, hospital stay, intraoperative blood loss and incident rate of complications in the observation group were less than those in the control group(all P<0.05). The positive rates of CD3+ cells and CD4+ cells and the CD4+/CD8+ ratio were higher, but the positive rate of CD8+ cells was lower in the observation group compared to the control group(all P<0.05). After operation, the scores of Karnofsky scale (KPS) significantly increased in both groups, and the KPS score of the observation group was higher than that of the control group(all P<0.05). ConclusionFor treating gastric stromal tumor, laparoscopic surgery has the advantages of less trauma, fast postoperative recovery and high safety, and has little effect on body′s immune function, and can improve the postoperative life quality of patients.

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