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目的探讨精细化环形电极宫颈锥切术（LEEP）对宫颈上皮内瘤变（CIN）患者人乳头瘤病毒（HPV）16/18感染及宫颈机能的影响。方法将80例CIN患者分成观察组及对照组，每组 40例。对照组采用冷刀宫颈锥切术治疗，观察组采用精细化LEEP术治疗。观察两组患者术后HPV16/18表达阳性率、宫颈机能及并发症发生情况。结果观察组患者术后3个月宫颈狭窄程度及宫颈修复情况均优于对照组，术后1年并发症发生率低于对照组，术后第6个月、第12个月HPV16/18表达阳性率均低于对照组（均P＜0.05）。结论采用精细化LEEP术治疗CIN患者疗效确切，术后并发症少，利于宫颈机能恢复，有效抑制HPV16/18感染。
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更新时间：2019-01-07
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精细化环形电极宫颈锥切术对宫颈上皮内瘤变患者人乳头瘤病毒16/18感染及宫颈机能的影响
Effect of refined loop electrosurgical excision procedure human papillomavirus 16/18 infection and cervical function in patients with cervical intraepithelial neoplasia
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- 英文简介
- 参考文献
ObjectiveTo investigate the effect of refined loop electrosurgical excision procedure（LEEP） on human papillomavirus (HPV) 16/18 infection and cervical function in the patients with cervical intraepithelial neoplasia (CIN). MethodsEighty patients with CIN were divided into observation group and control group, with 40 cases in each group. The control group was treated with cold-knife cervical conization, while the observation group was treated with refined LEEP. The positive expression rate of HPV16/18, cervical function and complications were observed after operation in the patients of both groups. ResultsCompared to the control group, the degree of cervical stenosis and cervical repairment at 3 months after operation were superior, the incident rate of complications at 1 year after operation was lower, and the positive expression rates of HPV16/18 at the 6th and 12th months after operation were lower in the observation group (all P＜0.05). ConclusionApplication of refined LEEP to CIN patients can obtain a definite efficacy, fewer postoperative complications, is beneficial to the cervical function recovery and effectively inhibits HPV16/18 infection.
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