ObjectiveTo study the effect of leuprolide combined with laparoscopic myomectomy on hormone levels,menstruation and the recurrence rate of hysteromyoma in the patients with hysteromyoma. MethodsEighty patients with hysteromyoma were enrolled and were divided into study group (n=40) and control group (n=40) according to random table method. The control group underwent laparoscopic myomectomy. The study group was administered leuprorelin for 3 months before operation then underwent laparoscopic myomectom.The levels of serum hormones,menstruation, hysteromyoma volume and recurrence rate of hysteromyoma were compared between the two groups. ResultsAfter treatment, the levels of luteinizing hormone, serum estradiol and follicular stimulating hormone in the study group were significantly lower than those in the control group (P＜0.05). After administration of leuprolide in the study group, no obvious changes in the menstrual duration and menstrual cycle were found compared to the levels before administration（P＞0.05）, but the menstrual volume, uterine volume and tumor volume was significantly less or smaller than those before treatment (P＜0.05). There was no significant difference in the operative duration between the two groups (P＞0.05). The intraoperative blood loss and pelvic drainage volume were significantly less, and the duration for ambulation and hospital stay were significantly shorter in the study group compared to the control group (P＜0.01). Half-year follow-up was conducted in all patients. In all cases, the uteruses recovered to the normal condition, the menstrual volume was normalized, anemia was relieved or disappeared, and no recrudesce occurred. ConclusionBefore laparoscopic myomectomy, application of leuprolide can obtain good clinical efficacy and safety, significantly reduce the serum hormone level of the patients, improve menstrual volume, and is worthy of application and promotion.

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