ObjectiveTo explore the application value of different methods of MRI for diagnosing temporal lobe epilepsy. MethodsA total of 225 patients were enrolled, including 110 patients in the control group and 115 patients in the epilepsy group. The volume of hippocampus was measured by conventional MRI then was compared between the two groups. And the epileptogenic side was evaluated in the epilepsy group. Measurement using diffusion weighted imaging (DWI) was performed in both groups, and the difference in the apparent diffusion coefficient (ADC) was compared. The change rule of NAA/(Cr+Cho) ratio was analyzed using 1H MRS in both groups, and the affected side and the contralateral side. ResultsThe volumes of left and right hippocampus in the epilepsy group were significantly smaller than those in the control group (P＜0.05). There were no significant differences in the NAA/(Cr+Cho) value and ADC value between the left and right hippocampus in the control group(P＞0.05). The NAA / (Cr+Cho) value was significantly lower and ADC value was significantly higher in the affected side of the epilepsy group compared to the contralateral side of the epilepsy group or the control group(P＜0.01). But there were no significant differences in the NAA/(Cr+Cho) value and ADC value between the contralateral side of the epilepsy group and the control group(P＞0.05). Conclusion1H-MRS combined with DWI is helpful for location of the epileptogenic side. The NAA/(Cr+Cho) ratio in the affected hippocampus decreases and the ADC value increases during the the epileptic attack, which reflects the change of metabolite concentration in the hippocampus.

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