ObjectiveTo investigate the clinical efficacy of intravitreal injection of conbercept combined with laser therapy for treating cystic macular edema(CME) secondary to branch retinal vein occlusion (BRVO). MethodsThirty-eight patients (38 eyes)were enrolled as objects, and were definitely diagnosed as CME secondary to BRVO by fundus examination,optical coherence tomography (OCT) and fundus fluorescein angiography(FFA). All patients received intravitreal injection of conbercept combined with laser therapy. The best corrected visual acuity, the results of OCT and FFA before treatment andwere compared among different time points (at 1 day, 1 week, 4 weeks and 8 weeks after treatment).ResultsAt 8 weeks after treatment, the visual acuity of 28 eyes(73.68%), 8 eyes(21.05%) and 2 eyes(5.26%) were improved, stable and decreased respectively. The central macular thickness before treatment, at 4 weeks and 8 weeks after treatment were (617.5±38.0)μm, (308.3±110.4)μm and (189.0±36.5)μmrespectively, and significant difference was found(P＜0.05). During the 1-month follow-up, transient ocular hypertension occurred in 4 cases (10.53%), but no adverse reactions including endoophthalmitis, uveitis, cataract and long-term ocular hypertension were observed. ConclusionIntravitreal injection of conbercept combined with laser therapy obtains obvious clinical efficacy for treating CME secondary to BRVO, can effectively improve naked visual acuity and is worthy of clinical application.

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