ObjectiveTo explore the clinical efficacy of laparoscopic intersphincteric resection (ISR) for treating lower rectal cancer. MethodsA total of 160 patients with low rectal cancer were enrolled as objects. Eighty patients undergoing laparoscopic ISR were enrolled as observation group and the other 80 patients undergoing open ISR as control group. The related indices were compared between the two groups, including operative duration, intraoperative blood loss, duration for postoperative anal exhaust, postoperative complications and recrudescence rate. The number of removal lymph nodes, pathological result and TNM clinical stage were observed in both group. The 5-year metastasis and survival were statistically analyzed. ResultsThere was no significant difference in the operative duration between the two groups（P＞0.05）. The intraoperative blood loss, duration for postoperative anal exhaust, duration for diet normalization and hospital stay were shorter in the observation group compared to the control group（P＜0.05）. There were no significant differences in the number of removal lymph nodes, tissue differentiation, TNM stage and Kirwan classification for anal function between the two groups（P＞0.05）. There was significant difference in the incident rate of complications between the two groups（P＜0.05）.There were no significant differences in the 5-year metastasis rate and 5-year survival rate between the two groups（P＞0.05）. ConclusionLaparoscopic ISR can achieve a therapeutic effect of total tumor resection, less surgical trauma, less blood loss, fast gastrointestinal function recovery and definite efficacy.

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