ObjectiveTo explore the clinical efficacy of flurbiprofen axetil for preventing postoperative sleep disturbance after percutaneous microwave ablation of hepatocellular carcinoma. MethodsForty patients undergoing percutaneous microwave ablation of hepatocellular carcinoma were randomly divided into observation group and control group, with 20 cases in each group. All the patients received total intravenous anesthesia and percutaneous microwave ablation of hepatocellular carcinoma. Within 3 days before operation, the observation group was intravenously administered flurbiprofen axetil (50 mg per time) at 9：00 and 17：00 every day. And the control group was administered fat emulsion of injection equal volume at the same time points. At 1 day, 3 days, and 6 days after operation, the Visual Aanalogue Scale (VAS) and Asens Insomnia Scale were used to evaluate the degree of pain and sleep condition for the patients respectively. ResultsCompared to the control group, The VAS scores and scores of Asens Insomnia Scale at 1day and 3 days after operation were significantly lower in the observation group(P＜0.05). There were no significant differences in the VAS score and score of Asens Insomnia Scale at 6 days after operation between the two groups（P＞0.05）. At 1day and 3 days after operation, the sleep disturbance was more severe in the control group compared to the observation group（P＜0.05）.At 6 days after operation, there was no significant difference in the sleep disturbance between the two groups（P＞0.05）. The incident rates of nausea and vomiting in the observation group and control group were 21.05%（4/19） and 26.32%（5/19）respectively, and no significant difference was found（P＞0.05）. ConclusionFlurbiprofen axetil significantly reduces the occurrence of postoperative sleep disturbance probably by alleviating postoperative pain in the patients undergoing microwave ablation of hepatocellular carcinoma.

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