ObjectiveTo investigate the effects of thoracoscopic and open lobectomy on inflammatory factors and immune function in the patients with non small cell lung cancer. MethodsSeventy-two patients with non small cell lung cancer were selected, and were divided into thoracoscope group and open group according to the operative methods. The thoracoscope group and the open group were treated with thoracoscopic and open lobectomy respectively. The related indices were compared between the two groups, including intraoperative blood loss, operation duration, incision length, number of removed lymph nodes, serum IL-6 level, C reactive protein level and immune function. ResultsCompared to the open group, the operation duration, intraoperative blood loss and incision length were less or shorter, but the number of removed lymph nodes was more in the thoracoscope group (P＜0.05). In both groups, the levels of IL-6 and CRP at 1d and 5 d after operation were higher than preoperative levels (P＜0.05). The levels of IL-6 and CRP at 1 d and 5 d in the open group were significantly higher than those in the thoracoscope group (P＜0.05).In both groups, the levels of IL-6 and CRP at 5 d after operation were lower than the levels at 1 d after operation(P＜0.05). In both groups, the levels of IgG, CD4+ and CD8+T lymphocytes, and CD4+/CD8+ after operation were lower than the preoperative levels (P＜0.05). The levels of IgG, CD4+ and CD8+T lymphocytes, and CD4+/CD8+ were lower in the thoracoscope group compared to the open group（P＜0.05）. ConclusionFull thoracoscopic lobectomy is obviously effective for non small cell lung cancer, can alleviate the inflammatory response of the patients and is beneficial to the rapid recovery of immune function to some extent. This approach is worthy of clinical promotion and application.

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