ObjectiveTo observe the effect of intravenous injection with parecoxib sodium combined with local infiltration with ropivacaine on postoperative pain in the patients with breast cancer. MethodsA total of 120 patients receiving surgery for breast cancer under general anesthesia were randomly divided into control group, parecoxib sodium group, ropivacaine group and combined group, with 30 cases in each group. No intervention was performed in the control group. The parecoxib sodium group and combined group were intravenously injection of parecoxib sodium 0.8 mg/kg at 15 min before skin incision. The ropivacaine group and combined group received local infiltration with 0.375% ropivacaine 20 mL around the surgical incision and drainage tube at the end of the surgery. Patient controlled analgesia after surgery was not performed in all groups. The complication within 48 hours after operation in 4 groups were recorded, including respiratory depression, dizziness, nausea and vomiting. The pain of the patients in each group was assessed at 2 h, 4 h, 8 h, 12 h, 24 h and 48 h after surgery using Visual Analogue Scoring (VAS).The cases receiving additional analgesics within 48 hours after operation were recorded. ResultsThere was no difference in the incident rate of adverse reactions (such as respiratory depression, dizziness, nausea and vomiting)within 48 hours after operation among the 4 groups（P＞0.05）. In the 4 group, the VAS scores were significantly higher at 4 h, 8 h, 12 h, 24 h and 48 h after operation compared with the score at 2 h after operation(P＜0.05). Compared with the control group, the VAS scores at 2 h, 4 h, and 8 h after operation decreased in the ropivacaine group(P＜0.05), the scores at 2 h, 4 h, 8 h and 12 h decreased in the ropivacaine group (P＜0.05) , and the scores at 2 h, 4 h, 8 h, 12 h, 24 h and 48 h decreased in the combined group (P＜0.05). Compared with the parecoxib group and the ropivacaine group, the VAS scores at 4 h, 8 h, 12 h, 24 h and 48 h after operation were lower in the combined group(P＜0.05). There was no significant difference in the proportion of the cases receiving additional analgesics at 48 h after surgery among the parecoxib group, the ropivacaine group and the combined group (P＞0.05). The proportion of the cases receiving additional analgesics in the control group was more than those of the other three groups (P＜0.05). ConclusionIntravenous injection of parecoxib sodium combined with local infiltration of ropivacaine can alleviate postoperative pain without increased incidence of adverse reactions in the patients receiving the surgery for breast cancer under general anesthesia.

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