ObjectiveTo analyze the clinical efficacy of GyroKnife stereotactic radiotherapy(SRT) combined with whole brain radiotherapy (WBRT) in the treatment of multiple brain metastasis. MethodsOf 76 patients with multiple brain metastases (2-4 lesions in each case, and the maximal diameter of lesion ≤4 cm), 36 patients were treated with SRT (control group) and 40 patients with SRT combined with WBRT (observation group). The local control rate of intracranial tumor, intracranial distant recurrence rate and total survival rate were compared between the two groups. ResultsThere were no significant differences in the objective response rate and local control rate of intracranial tumor between the two groups（P＞0.05）. The intracranial distant recurrence rate of the control group was significant higher than that of the observation group（P＜0.05）. There was no significant difference in the median survival time between the control group and observation group（12 month vs. A3 months, P＞0.05）. ConclusionsSRT can achieve similar survival time and local control rate as WBRT+SRT for brain metastases (2-4 lesions). But the rate of intracranial distant recurrence increases, so the salvage therapy is necessary.

无