ObjectiveTo observe the relation of the serum angiogenin-2(Ang-2) with BNP concentration and left ventricular ejection fraction in the patients with chronic heart failure, thereby to evaluate the diagnostic value of Ang-2 for heart failure. MethodsSixteen chronic heart failure patients from the First Affiliated Hospital of Guangxi Medical University were enrolled as heart failure group. All of the patients were diagnosed as dilated cardiomyopathy by echocardiography and had no abnormal finding of coronary angiography. Sixteen healthy cases participating in physical examination during the same period were enrolled as control group. The data of clinical laboratory test and results of echocardiography were collected. The serum Ang-2 and BNP levels were detected. ResultsThere were no significant differences in the age, gender, weight, height, blood pressure and blood lipids between the two groups（P＞0.05）. The BNP level was higher and the ejection fraction was lower in the heart failure group compared to the control group（P＜0.05）. The Ang-2 level of the heart failure group was higher than that of the control group (P＜0.05). In the heart failure group, the serum Ang-2 level positively correlated with left ventricular end-systolic diameter relation and left ventricular end-diastolic diameter (r=0.281, P=0.026;r=0.256, P=0.003) , negatively correlated with left ventricular ejection fraction (r=0.280, P=0.030), and positively correlated with serum BNP concentration (r=0.194, P=0.028). ConclusionIn the patients with chronic heart failure, the serum Ang-2 concentration significantly increases as the heart function declines, which suggests that Ang-2 is closely related to chronic heart failure. This may provide new method and idea for the prevention and treatment of heart failure.

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