当前位置:首页 / 宁养胃肠道肿瘤患者的生存率及预后分析▲
论著 | 更新时间:2018-07-03
|
宁养胃肠道肿瘤患者的生存率及预后分析▲
Survival rate and prognosis of gastrointestinal cancer patients from hospice care

微创医学 201813卷03期 页码:297-299

作者机构:广西医科大学第一附属医院麻醉科,南宁市530021

基金信息:▲基金项目:国家自然科学基金(编号:81560500、81160289);广西科学研究与技术开发计划课题(编号:桂科攻1598012-31)

*通信作者

DOI:DOI:10.11864/j.issn.1673.2018.03.07

  • 中文简介
  • 英文简介
  • 参考文献
目的通过分析宁养胃肠道肿瘤患者的临床资料,分析宁养胃肠道肿瘤患者的生存率及其影响因素,以期为肿瘤的临床防治提供参考。方法收集广西医科大学第一附属医院宁养院2010年1月至2012年12月收治的190例胃肠道肿瘤患者的病历资料,进行回顾性分析并随访至2013年6月30日(或患者死亡),用Kaplan-Meier法计算中位生存期和生存率,log-rank法比较生存率差异,Cox比例风险模型进行多因素分析。结果宁养胃肠道肿瘤患者的中位生存期为14.2个月,平均生存期为22.7个月,1年累积生存率为(59.5±3.6)%,3年累积生存率为(19.8±2.9)%。生存分析显示,患者是否接受过手术治疗、化疗、出现癌性疼痛的时间和疼痛治疗史是与患者生存预后相关的主要因素;Cox回归分析显示,是否接受过手术治疗、出现癌性疼痛的时间和疼痛治疗史是影响宁养胃肠道肿瘤患者预后的独立危险因素。结论影响宁养胃肠道肿瘤患者生存预后的独立危险因素包括:既往相关手术史、出现癌性疼痛的时间和疼痛治疗史。疾病早期诊断、接受积极有效的手术治疗并进行适当的辅助化疗,同时尽早进行有效的疼痛治疗对于延长宁养胃肠道肿瘤患者的生存时间、改善生存质量具有重要意义。
ObjectiveTo explore the survival rate and its influencing factors in the gastrointestinal cancer patients from hospice care by analyzing the clinical data, thereby to provide reference for clinical prevention and treatment of cancer. MethodsData of 190 patients with gastrointestinal cancer were collected and retrospectively analyzed. The patients were hospitalized in the hospice care of the First Affiliated Hospital of Guangxi Medical University. The cut-off date for the follow-up was June 30th, 2013 (or the date of death). The Kaplan-Meier method was used to calculate the median survival time and survival rate, and the log-rank test was used to assess the the difference in survival rate.Multivariate analysis was performed using the Cox proportional hazard regression model. ResultsIn the gastrointestinal cancer patients from hospice care, the median survival time, average survival time, 1-year cumulative survival rate and 3-year cumulative survival rate were 14.2 months, 22.7 months, (59.5±3.6)% and (19.8±2.9)%, respectively. The results of univariate analysis revealed that the factors related to survival and prognosis included surgical therapy, chemotherapy, the onset time of cancerous pain and the therapy history for pain. Cox regression analysis found that operative therapy, the onset time of cancerous pain and the therapy history for pain were the independent risk factors influencing the prognosis in the patients with gastrointestinal cancer from hospice care. ConclusionRelated surgical therapy in the past, the onset time of cancerous pain and the therapy history for pain are the independent risk factors influencing the prognosis in the patients with gastrointestinal cancer from hospice care. Early diagnosis, effective operation, proper adjuvant chemotherapy and effective early anti-pain treatment are significant for prolonging the survival time and improving the quality in the gastrointestinal cancer patients from hospice care.

1902

浏览量

845

下载量

0

CSCD

工具集