ObjectiveTo investigate the diagnostic value of contrast-enhanced ultrasound (CEUS) guided lung biopsy for peripheral lung cancer,and the relationship between enhancement patterns and microvessel density(MVD) in lung tumors with different types. MethodsA total of 42 patients with peripheral lung occupying lesions(42 lesions) were included in the study, and all of the lesions were clearly observed in chest CT and ultrasound. CEUS was used to measure the peak intensity and enhancement index. Then CEUS-guided percutaneous biopsy was performed in the obviously enhanced area of the lesions, and the necrotic area without enhancement should be avoided. Pathological examination and MVD counting were conducted in all specimens. ResultsOf 42 patients receiving percutaneous biopsy, 22 cases were pathologically diagnosed as adenocarcinoma (2 cases with mucinous adenocarcinoma were involved in), 8 cases as moderately- or well-differentiated phosphorus cancer, 6 cases as poorly-differentiated squamous cell carcinoma, and 6 cases as small cell carcinoma. The MVD, peak intensity and enhancement index of the lung adenocarcinoma were higher than those of the squamous cell carcinoma (P＜0.05). The peak intensity and enhancement index measured by CEUS were positively correlated with MVD in either lung adenocarcinoma or squamous cell carcinoma(P＜0.01). Necrosis within the tumor was found in 12 cases (54.5%) of adenocarcinoma, 9 cases (64.2%) of squamous cell carcinoma and 6 cases (66.6%) of small cell carcinoma. ConclusionCEUS can reflect the difference in enhancement patterns among lung tumors with different types. It is beneficial to the diagnosis and differential diagnosis of peripheral lung cancers, accurate guidance for the puncture and biopsy and analysis on tumor MVD, and can be the basis for anti-vascular therapy.

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