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目的观察恩再适对奥沙利铂所致周围神经毒性的影响。方法选取280例应用含奥沙利铂方案联合化疗的结直肠癌患者，其中使用恩再适治疗的150例患者为治疗组，未使用恩再适治疗的130例患者为对照组。比较两组周围神经毒性的发生率。结果与对照组相比，治疗组奥沙利铂神经毒性发生率明显下降，差异有统计学意义(P＜0.05)。结论恩再适对奥沙利铂所致的周围神经毒性有较好的防治效果。
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临床研究
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更新时间：2018-03-02
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恩再适防治奥沙利铂相关神经毒性的临床观察▲
Prevention effect of analgecine on oxaliplatin-related neurotoxicity
微创医学 201813卷01期 页码：60-61+102
作者机构：广西医科大学附属肿瘤医院消化道肿瘤内科，南宁市530021
基金信息：▲基金项目：广西区卫生计生委科研项目（编号：Z2015717）
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ObjectiveTo observe the effect of analgecine on oxaliplatin-induced peripheral neurotoxicity. MethodsA total of 280 colorectal cancer patients receiving combined chemotherapy containing oxaliplatin were enrolled. Administration of analgecine was performed in 150 patients(treatment group) , and was not performed in the other 130 patients(control group). The incident rate of peripheral neurotoxicity was compared between the two groups. ResultsThe incident rate of oxaliplatin-induced related neurotoxicity in treatment group was lower than that in the control group (P＜0.05). ConclusionAnalgecine obtains a good prevention effect on oxaliplatin-induced peripheral neurotoxicity.
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