ObjectiveTo investigate the significance of IL-37 and IL-39 in treatment using phonophoresis of Brassica rapa, fecal microbiota transplantation(FMT) and trastuzumab for the rabbits with advanced gastric cancer and evaluation for survival time. MethodsEighty-five rabbits with advanced gastric cancer and ascites were randomly divided into experimental group (n=45) and control group (n=40), Basic enemata and alleviative treatment were conducted in both groups. The experimental group also received phonophoresis of Brassica rapa and FMT combined with trastuzumab, and the control group received hyperthermic intraperitoneal chemotherapy with cisplatin combined with trastuzumab. The IL-37 and IL-39 levels in serum and ascitic fluid, the gastrointestinal function recovery (including the recovery of bowel sound, anal exhaust and cacation) and survival time were observed in both groups. ResultsAt the 48 h, 72 h, 96 h and 120 h after treatment, the differences of waist circumference in the experimental group were more than those in the control group（P＜0.05）. The IL-37 and IL-39 levels in serum and ascitic fluid were lower in the experimental group compared to the control group（P＜0.05）.The duration for the first anal cacation was shorter and the median survival time was longer in the experimental group compared to the control group（P＜0.05）. ConclusionPhonophoresis of Brassica rapa and FMT combined with trastuzumab can obtain a significant efficacy for the rabbits with advanced gastric cancer and can significantly prolong the survival time. The IL-37 and IL-39 in serum and ascitic fluid can be used as indicators for predicting the therapeutic efficacy and survival time in the rabbits with advanced gastric cancer.

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