ObjectiveTo explore the clinical efficacy and safety of the purse-string suture using titanium clip combined with nylon endoloop for perforation during the endoscopic treatment of gastric stromal tumor. MethodsSeventeen patients suffering from perforation during the endoscopic treatment of gastric stromal tumors were enrolled. Purse-string suture using titanium clip combined with nylon endoloop was performed to close the perforation. The efficacy of this approach was analyzed. ResultsComplete resection or excavation of lesions was performed in all of 17 cases. The operative duration was （116.7±19.1）min and the intraopeartive blood loss was （11.5±7.8）mL. The duration for closing the perforation with pouch-string suture and postoperative hospital stay were (16.2±3.5)min and (6.1±2.2) d respectively. And (5.3±1.8)titanium clips were used during the suture. No complications occurred after operation including delayed bleeding, recurrent gastric perforation and peritonitis. No special complications were found in any cases during the 4-week follow-up. After 3 months, the gastroscope showed that wound healed well. ConclusionThe purse-string suture using titanium clip combined with nylon endoloop can effectively close the gastric perforation during endoscopic treatment safely and effectively, and is less time consuming and less difficult for operation. This approach is worthy of clinical promotion and application.

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